3-Amino-4-bromo-6-chloropyridazine

Base Information

• Chemical Name: 3-Amino-4-bromo-6-chloropyridazine
• CAS No.: 446273-59-2
• Molecular Formula: C4H3 Br Cl N3
• Molecular Weight: 208.445
• Hs Code.: 2933990090
• Mol file: 446273-59-2.mol

Synonyms:3-Amino-4-bromo-6-chloropyridazine;4-Bromo-6-chloro-3-pyridazinamine

Chemical Property of 3-Amino-4-bromo-6-chloropyridazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 385.369oC at 760 mmHg
• PKA: 1.93±0.10(Predicted)
• Flash Point: 186.865oC
• PSA: 51.80000
• Density: 1.960
• LogP: 2.05590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-6-chloropyridazin-3-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-6-chloropyridazin-3-amine is a compound involved in the preparation of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.

Technology Process of 3-Amino-4-bromo-6-chloropyridazine

There total 2 articles about 3-Amino-4-bromo-6-chloropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) → 4-bromo-6-chloro-3-pyridazineamine (446273-59-2)

Guidance literature:

With bromine; sodium hydrogencarbonate; In methanol; at 0 - 20 ℃; for 16h;

Reference yield:

→ 4-bromo-6-chloro-3-pyridazineamine (446273-59-2)

Guidance literature:

Reference yield: 95.0%

4-bromo-6-chloro-3-pyridazineamine (446273-59-2) + (4-phenylpiperidin-4-ylmethyl)carbamic acid tert-butyl ester → Tert-butyl ((1-(3-amino-6-chloropyridazin-4-yl)-4-phenylpiperidin-4-yl)methyl)carbamate

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 20h; Inert atmosphere;

upstream raw materials:

6-chloro-pyridazin-3-ylamine

Downstream raw materials:

6-chloro-4-methoxypyridazin-3-amine

6-chloro-4-(2,4-dimethylphenyl)-3-pyridazineamine

8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride

6-chloro-4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazin-3-ylamine