8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride

Base Information

• Chemical Name: 8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride
• CAS No.: 933034-89-0
• Molecular Formula: C6H4BrCl2N3
• Molecular Weight: 268.928
• Hs Code.: 2933990090
• Mol file: 933034-89-0.mol

Synonyms:8-Bromo-6-chloroimidazo[1,2-b]pyridazine HCl;8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride

Chemical Property of 8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride

Chemical Property:

• PSA: 30.19000
• LogP: 2.94720

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-6-chloroimidazo-[1,2-b]pyridazine hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride

There total 1 articles about 8-bromo-6-chloroimidazo[1,2-b]pyridazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloroethanal (107-20-0) + 4-bromo-6-chloro-3-pyridazineamine (446273-59-2) → 8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride (933034-89-0)

Guidance literature:

In ethanol; at 50 ℃;

Reference yield: 86.0%

2-fluoro-4-methanesulfonylaniline (832755-13-2) + 8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride (933034-89-0)

Guidance literature:

With potassium n-butoxide; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride (933034-89-0) + 4-methoxy-benzylamine (2393-23-9) → 6-chloro-N-(4-methoxy-benzyl)-imidazo[1,2-b]pyridazin-8-amine (933035-05-3)

Guidance literature:

With triethylamine; In ethanol; at 90 ℃; for 24h;

upstream raw materials:

2-chloroethanal

4-bromo-6-chloro-3-pyridazineamine

Downstream raw materials:

6-chloro-N-(4-methoxy-benzyl)-imidazo[1,2-b]pyridazin-8-amine

N₁-(6-chloroimidazo[1,2-b]pyridazin-8-yl)benzene-1,4-diamine

6-chloro-N-(4-ethoxy-phenyl)-imidazo[1,2-b]pyridazin-8-amine

3,8-dibromo-6-chloroimidazo[1,2-b]pyridazine

Refernces

• 1、 -. "Fused heterocyclic compounds useful as kinase modulators". Page/Page column 27. . Retrieved 2010/11/26.