N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide

Base Information

• Chemical Name: N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide
• CAS No.: 1361483-73-9
• Molecular Formula: C₁₆H₁₃ClN₄O₂S
• Molecular Weight: 360.824
• Mol file: 1361483-73-9.mol

Synonyms:N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide

Chemical Property of N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide

There total 2 articles about N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.6%

4-(6-chloropyrimidin-4-yl)-N-methylthiazol-2-amine (932738-80-2) + 4-methoxy-benzoyl chloride (100-07-2) → N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide (1361483-73-9)

Guidance literature:

With triethylamine; In toluene; at 100 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jm201590g

Reference yield:

C6H4BrClN2O → N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide (1361483-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 2 h / 20 °C

2: triethylamine / toluene / 10 h / 100 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; water; toluene;

DOI:10.1021/jm201590g

Reference yield: 71.2%

N-[4-(6-chloropyrimidin-4-yl)-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide (1361483-73-9) + isopropylamine (75-31-0) → N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide (932738-46-0)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 80 ℃; for 16h;

DOI:10.1021/jm201590g

upstream raw materials:

4-(6-chloropyrimidin-4-yl)-N-methylthiazol-2-amine

4-methoxy-benzoyl chloride

Downstream raw materials:

4-hydroxy-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide

4-(2-fluoroethoxy)-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide

N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-methoxy-N-methylbenzamide