3-nitro-4-(1H)-quinolone

Base Information

• Chemical Name: 3-nitro-4-(1H)-quinolone
• CAS No.: 125836-07-9
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.158
• Mol file: 125836-07-9.mol

Synonyms:3-nitro-4-(1H)-quinolone

Chemical Property of 3-nitro-4-(1H)-quinolone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Nitroquinolin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-nitro-4-(1H)-quinolone

There total 3 articles about 3-nitro-4-(1H)-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-<2-nitroethylideneamino>benzoic acid (121845-92-9) → 3-nitro-4-(1H)-quinolone (125836-07-9)

Guidance literature:

With potassium carbonate; In acetic anhydride; at 140 ℃; for 0.25h;

DOI:10.1016/0040-4020(89)80121-8

Reference yield: 41.0%

(E)-2-(2-nitrovinylamino)benzoic acid (152904-43-3,298188-18-8) → 3-nitro-4-(1H)-quinolone (125836-07-9)

Guidance literature:

(E)-2-(2-nitrovinylamino)benzoic acid; With acetic anhydride; at 100 ℃; for 1h;

With sodium acetate; at 120 ℃;

DOI:10.1021/jm5012808

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 3-nitro-4-(1H)-quinolone (125836-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / HCl / H₂O / 18 h / Ambient temperature

2: 42 percent / potassium carbonate / acetic anhydride / 0.25 h / 140 °C

With hydrogenchloride; potassium carbonate; In water; acetic anhydride;

DOI:10.1016/0040-4020(89)80121-8

upstream raw materials:

2-<2-nitroethylideneamino>benzoic acid

anthranilic acid

(E)-2-(2-nitrovinylamino)benzoic acid

Downstream raw materials:

3-nitro-4-aminoquinoline

N-(4-Amino-quinolin-3-yl)-benzamide

N-(4-Amino-quinolin-3-yl)-4-chloro-benzamide

3-amino-1,4-dihydroquinoline-4-one

Refernces

• 1、 Nicholson, John R.,Singh, Gurdial,McCullough, Kevin J.,Wightman, Richard H.. "CYCLOADDITION REACTIONS OF N-ALKOXYCARBONYL-4-QUINOLONES". . p. 889 - 908. Retrieved 2007/10/02.