6-fluoro-7-methoxy-1-oximinotetralin tosylate

Base Information

Chemical Name:6-fluoro-7-methoxy-1-oximinotetralin tosylate
CAS No.:103347-04-2
Molecular Formula:C₁₈H₁₈FNO₄S
Molecular Weight:363.41
Hs Code.:

Synonyms:6-fluoro-7-methoxy-1-oximinotetralin tosylate

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Chemical Property of 6-fluoro-7-methoxy-1-oximinotetralin tosylate

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Technology Process of 6-fluoro-7-methoxy-1-oximinotetralin tosylate

There total 5 articles about 6-fluoro-7-methoxy-1-oximinotetralin tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 103347-03-1
6-fluoro-7-methoxy-1-oximinotetralin

: 98-59-9
p-toluenesulfonyl chloride

: 103347-04-2
6-fluoro-7-methoxy-1-oximinotetralin tosylate

Guidance literature:: With pyridine; at 25 ℃; for 3h;
DOI:10.1021/jm00159a010

Reference yield:

: 321-28-8
1-fluoro-2-methoxybenzene

: 103347-04-2
6-fluoro-7-methoxy-1-oximinotetralin tosylate

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / AlCl₃ / 1,2-dichloro-ethane / 0.33 h / 65 °C

2: 62 percent / 10percent aq. HClO₄, H₂ / 10percent Pd/C / ethanol; acetic acid / 3.5 h / 3102.9 Torr / Ambient temperature

3: 65 percent / methanesulfonic acid (MSA) / trifluoroacetic acid / 0.75 h / 100 °C

4: 94 percent / hydroxylamine hydrochloride, aq. K₂CO₃ / ethanol / 2 h / Heating

5: 97 percent / pyridine / 3 h / 25 °C

With pyridine; aluminium trichloride; perchloric acid; methanesulfonic acid; hydroxylamine hydrochloride; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; acetic acid; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.1021/jm00159a010

Reference yield:

: 347-63-7
γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid

: 103347-04-2
6-fluoro-7-methoxy-1-oximinotetralin tosylate

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / 10percent aq. HClO₄, H₂ / 10percent Pd/C / ethanol; acetic acid / 3.5 h / 3102.9 Torr / Ambient temperature

2: 65 percent / methanesulfonic acid (MSA) / trifluoroacetic acid / 0.75 h / 100 °C

3: 94 percent / hydroxylamine hydrochloride, aq. K₂CO₃ / ethanol / 2 h / Heating

4: 97 percent / pyridine / 3 h / 25 °C

With pyridine; perchloric acid; methanesulfonic acid; hydroxylamine hydrochloride; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; acetic acid; trifluoroacetic acid;
DOI:10.1021/jm00159a010