N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide

Base Information

• Chemical Name: N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide
• CAS No.: 1486470-31-8
• Molecular Formula: C₂₁H₂₁N₃O₂
• Molecular Weight: 347.417
• Mol file: 1486470-31-8.mol

Synonyms:N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide

Chemical Property of N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide

There total 5 articles about N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

Benzoylformic acid (611-73-4) + 5-amino-1-phenyl-3-tert-butylpyrazole (126208-61-5) → N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide (1486470-31-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h; Cooling with ice;

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide (1486470-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / chloroform / 0 - 5 °C

2: sodium hydroxide / methanol / 0.5 h / 0 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 20 °C / Cooling with ice

With aluminum (III) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; chloroform;

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → N-(3-t-butyl-1-phenyl-1H-pyrazol-5-yl)-2-oxo-2-phenylacetamide (1486470-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 20 °C / Cooling with ice

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

upstream raw materials:

benzene

phenylglyoxylic acid ethyl ester

Benzoylformic acid

5-amino-1-phenyl-3-tert-butylpyrazole