(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

Base Information

Chemical Name:(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine
CAS No.:147879-44-5
Molecular Formula:C₁₇H₂₇NO₂
Molecular Weight:277.407
Hs Code.:

Synonyms:(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

Chemical Property:

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Technology Process of (S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

There total 10 articles about (S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147879-42-3
N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

: 147879-44-5
(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

Guidance literature:: With hydrogen; nickel; In methanol; for 48h; under 3040 Torr; Yield given; Ambient temperature;
DOI:10.1021/jo00064a013

Reference yield:

: 189996-60-9
2,3-O-isopropylidene-D-erythrose

: 147879-44-5
(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, r.t, 20 h

2: 90 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature

4: 1.) phenyllithium / 1.) cyclohexane, diethyl ether, -40 deg C, 1 h, 2.) diethyl ether, -10 deg C to r.t., 2 h

5: H₂ / Raney nickel / methanol / 48 h / 3040 Torr / Ambient temperature

With n-butyllithium; hydrogen; phenyllithium; palladium on activated charcoal; nickel; In methanol;
DOI:10.1021/jo00064a013

Reference yield:

: 85254-46-2,126575-56-2
2,3-(isopropylidenedioxy)-4,4-dihydroxybutanic acid lactone

: 147879-44-5
(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, reflux, 1 h

2: diethyl ether / 0 - 5 °C

3: 54 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 5 °C

4: 90 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature

6: 1.) phenyllithium / 1.) cyclohexane, diethyl ether, -40 deg C, 1 h, 2.) diethyl ether, -10 deg C to r.t., 2 h

7: H₂ / Raney nickel / methanol / 48 h / 3040 Torr / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; phenyllithium; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo00064a013