N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

Base Information

Chemical Name:N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine
CAS No.:147879-42-3
Molecular Formula:C₁₉H₃₂N₂O₂
Molecular Weight:320.475
Hs Code.:

Synonyms:N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

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Chemical Property of N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

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Technology Process of N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

There total 9 articles about N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 189996-60-9
2,3-O-isopropylidene-D-erythrose

: 147879-42-3
N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, r.t, 20 h

2: 90 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature

4: 1.) phenyllithium / 1.) cyclohexane, diethyl ether, -40 deg C, 1 h, 2.) diethyl ether, -10 deg C to r.t., 2 h

With n-butyllithium; hydrogen; phenyllithium; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00064a013

Reference yield:

: 85254-46-2,126575-56-2
2,3-(isopropylidenedioxy)-4,4-dihydroxybutanic acid lactone

: 147879-42-3
N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, reflux, 1 h

2: diethyl ether / 0 - 5 °C

3: 54 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 5 °C

4: 90 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature

6: 1.) phenyllithium / 1.) cyclohexane, diethyl ether, -40 deg C, 1 h, 2.) diethyl ether, -10 deg C to r.t., 2 h

With lithium aluminium tetrahydride; n-butyllithium; hydrogen; phenyllithium; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo00064a013

Reference yield:

: 139727-13-2
(4S,5R)-2,2-Dimethyl-4-(2-methyl-1-propenyl)-5-(hydroxymethyl)-1,3-dioxolane

: 147879-42-3
N'-[(S)-1-((4R,5S)-5-Isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenyl-ethyl]-N,N-dimethyl-hydrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature

3: 1.) phenyllithium / 1.) cyclohexane, diethyl ether, -40 deg C, 1 h, 2.) diethyl ether, -10 deg C to r.t., 2 h

With hydrogen; phenyllithium; palladium on activated charcoal; In methanol;
DOI:10.1021/jo00064a013