tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate
CAS No.:1443209-19-5
Molecular Formula:C₃₂H₄₃NO₆SSi
Molecular Weight:597.848
Hs Code.:

Synonyms:tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

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Chemical Property of tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

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Technology Process of tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

There total 3 articles about tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 1443209-19-5
tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 0 - 20 °C / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.5 h

3.2: 12 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1443209-19-5
tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 0 - 20 °C / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.5 h

3.2: 12 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 120687-94-7
3-t-butyldimethylsilyloxybenzoic acid methyl ester

: 1443209-19-5
tert-butyl 4-((2-(((3-((tert-butyldimethylsilyl)oxy)benzyl)oxy)carbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-caboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.33 h / 0 - 20 °C / Inert atmosphere; Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.5 h

2.2: 12 h / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;