8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

Base Information

Chemical Name:8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone
CAS No.:137208-03-8
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

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Chemical Property of 8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

Chemical Property:

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Technology Process of 8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

There total 5 articles about 8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 137208-01-6
4-(2-anisyl)-8-bromomethyl-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

: 64-19-7,77671-22-8
acetic acid

: 137208-03-8
8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

Guidance literature:: With triethylamine; at 100 ℃; for 0.5h;
DOI:10.1248/cpb.39.2009

Reference yield:

: 578-57-4
2-bromoanisole

: 137208-03-8
8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1a) Mg, 1b) CdCl₂ / 1a) ether, 1b) 30 min, r.t., 2) THF, 1 h, reflux

2: hydrazine hydrate / ethanol / 2 h / 80 °C

3: 38 percent / N-bromosuccinimide, benzoylperoxide / CCl₄ / 20 h / Heating

4: 53 percent / triethylamine / 0.5 h / 100 °C

With N-Bromosuccinimide; Perbenzoic acid; hydrazine hydrate; magnesium; triethylamine; cadmium(II) chloride; In tetrachloromethane; ethanol;
DOI:10.1248/cpb.39.2009

Reference yield:

: 56611-62-2
3,5-dimethyl-4-ethoxycarbonyl-phthalic anhydride

: 137208-03-8
8-acetoxymethyl-4-(2-anisyl)-7-ethoxycarbonyl-6-methyl-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1a) Mg, 1b) CdCl₂ / 1a) ether, 1b) 30 min, r.t., 2) THF, 1 h, reflux

2: hydrazine hydrate / ethanol / 2 h / 80 °C

3: 38 percent / N-bromosuccinimide, benzoylperoxide / CCl₄ / 20 h / Heating

4: 53 percent / triethylamine / 0.5 h / 100 °C

With N-Bromosuccinimide; Perbenzoic acid; hydrazine hydrate; magnesium; triethylamine; cadmium(II) chloride; In tetrachloromethane; ethanol;
DOI:10.1248/cpb.39.2009