(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

Base Information

Chemical Name:(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate
CAS No.:96555-54-3
Molecular Formula:C₂₂H₃₇O₇PSi
Molecular Weight:472.591
Hs Code.:

Synonyms:(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

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Chemical Property of (R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

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Technology Process of (R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

There total 6 articles about (R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 96555-53-2
(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

: (Z)-(R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(dimethoxy-phosphoryl)-hex-5-enoic acid (R)-1-phenyl-ethyl ester

: 96555-54-3
(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

Guidance literature:: With 1H-imidazole; In dichloromethane; for 8h; Ambient temperature;
DOI:10.1021/jm00393a030

Reference yield:

: 96575-20-1
(3R,1'R)-methyl 1'-phenylethyl 3-hydroxypentanedioate

: 96555-54-3
(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT

2: 84 percent / imidazole / CH₂Cl₂ / 8 h / Ambient temperature

With 1H-imidazole; n-butyllithium; In dichloromethane;
DOI:10.1021/jm00393a030

Reference yield:

: 96555-51-0
(3R,1'R)-methyl 1'-phenylethyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate

: 96555-54-3
(R)-dimethyl <<3-<(tert-butyldimethylsilyl)oxy>-4-<<(R)-phenylethoxy>carbonyl>butyryl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / aq. HF / acetonitrile / 1.25 h / Ambient temperature

2: 1.) N-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT

3: 84 percent / imidazole / CH₂Cl₂ / 8 h / Ambient temperature

With 1H-imidazole; n-butyllithium; hydrogen fluoride; In dichloromethane; acetonitrile;
DOI:10.1021/jm00393a030