C₂₂H₂₁BrFNO₃

Base Information

Chemical Name:C₂₂H₂₁BrFNO₃
CAS No.:1160359-85-2
Molecular Formula:C₂₂H₂₁BrFNO₃
Molecular Weight:446.316
Hs Code.:

C<sub>22</sub>H<sub>21</sub>BrFNO<sub>3</sub>

Synonyms:C₂₂H₂₁BrFNO₃

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Chemical Property of C₂₂H₂₁BrFNO₃

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Technology Process of C₂₂H₂₁BrFNO₃

There total 6 articles about C₂₂H₂₁BrFNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1128105-87-2
C₁₄H₁₃BrFNO₂

: 2746-25-0
p-Methoxybenzyl bromide

: 1160359-85-2
C₂₂H₂₁BrFNO₃

Guidance literature:: C₁₄H₁₃BrFNO₂; With sodium hydride; In tetrahydrofuran; for 0.5h; Inert atmosphere;

p-Methoxybenzyl bromide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml2000438

Reference yield:

: 1128105-86-1
C₁₅H₁₃BrFNO₃

: 1160359-85-2
C₂₂H₂₁BrFNO₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydroxide / methanol / 16 h / 20 °C / Inert atmosphere

2.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / -10 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol; dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; trifluoro-[1,3,5]triazine; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml2000438

Reference yield:

: 1282036-04-7
C₁₄H₁₀BrF₂NO₂

: 1160359-85-2
C₂₂H₂₁BrFNO₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol; dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ml2000438