2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

Base Information

Chemical Name:2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline
CAS No.:124993-45-9
Molecular Formula:C₂₅H₂₁N₅O₃
Molecular Weight:439.473
Hs Code.:

Synonyms:2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

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Chemical Property of 2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

Chemical Property:

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Technology Process of 2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

There total 5 articles about 2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-Methoxy-5-[4-(quinolin-2-ylmethoxy)-benzyloxy]-benzonitrile

: 124993-45-9
2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

Guidance literature:: With sodium azide; pyridine hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 96h;
DOI:10.1021/jm00166a017

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 124993-45-9
2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 50 °C / overnight

2: SOCl₂ / CHCl₃ / Ambient temperature; overnight

3: K₂CO₃ / dimethylformamide / 60 °C

4: NaN₃, pyridine hydrochloride / dimethylformamide / 96 h / 100 °C

With thionyl chloride; sodium azide; pyridine hydrochloride; potassium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a017

Reference yield:

: 150235-40-8
[4-(quinolin-2-ylmethoxy)phenyl]methanol

: 124993-45-9
2-{4-[3-Methoxy-5-(1H-tetrazol-5-yl)-phenoxymethyl]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CHCl₃ / Ambient temperature; overnight

2: K₂CO₃ / dimethylformamide / 60 °C

3: NaN₃, pyridine hydrochloride / dimethylformamide / 96 h / 100 °C

With thionyl chloride; sodium azide; pyridine hydrochloride; potassium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a017