N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

Base Information

Chemical Name:N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide
CAS No.:1379457-26-7
Molecular Formula:C₂₃H₂₆FN₃O₆
Molecular Weight:459.474
Hs Code.:

Synonyms:N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

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Chemical Property of N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

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Technology Process of N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

There total 2 articles about N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 82130-75-4,114784-20-2,121961-93-1,101999-38-6
dihydro-4-(benzyloxy)-2(3H)-furanone

: 181997-31-9
N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

: 1379457-26-7
N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

Guidance literature:: N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide; With dimethylaluminum chloride; In hexane; dichloromethane; at 20 ℃;

dihydro-4-(benzyloxy)-2(3H)-furanone; In hexane; dichloromethane; at 20 ℃; for 4h;

In hexane; dichloromethane; pH=7; aq. phosphate buffer;
DOI:10.5012/bkcs.2012.33.4.1310

Reference yield:

: 100-39-0
benzyl bromide

: 1379457-26-7
N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(l) oxide / dichloromethane / 10 h / 20 °C

2.1: dimethylaluminum chloride / hexane; dichloromethane / 20 °C

2.2: 4 h / 20 °C

2.3: pH 7 / aq. phosphate buffer

With dimethylaluminum chloride; silver(l) oxide; In hexane; dichloromethane;
DOI:10.5012/bkcs.2012.33.4.1310

Reference yield: 99.0%

: 1379457-26-7
N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide

: N-(((S)-3-(4-((S)-4-(benzyloxy)-2-oxo-pyrrolidin-1-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)acetamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 4.33333h; Cooling with ice;
DOI:10.5012/bkcs.2012.33.4.1310