4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

Base Information

Chemical Name:4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide
CAS No.:1378078-72-8
Molecular Formula:C₁₈H₁₉N₅O₃S
Molecular Weight:385.447
Hs Code.:

Synonyms:4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

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Chemical Property of 4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

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Technology Process of 4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

There total 6 articles about 4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377581-87-7
4-Isopropoxy-3-isothiocyanato-benzamide

: 116532-14-0
4-amino-1,3-dihydro-benzoimidazol-2-one hydrochloride

: 1378078-72-8
4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 65 ℃; for 2h;

Reference yield:

: 400-94-2
4-fluoro-3-nitrobenzoyl chloride

: 1378078-72-8
4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / water; tetrahydrofuran / 0.58 h / 0 °C

2: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 - 23 °C

3: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 23 °C

4: sodium hydrogencarbonate / chloroform; water / 3.17 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 65 °C

With ammonium hydroxide; sodium tetrahydroborate; nickel(II) chloride hexahydrate; potassium hexamethylsilazane; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; chloroform; water; dimethyl sulfoxide; toluene;

Reference yield:

: 349-02-0
4-fluoro-3-nitrobenzamide

: 1378078-72-8
4-Isopropoxy-3-[3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yl)-thioureido]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 - 23 °C

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 23 °C

3: sodium hydrogencarbonate / chloroform; water / 3.17 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 65 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; potassium hexamethylsilazane; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; chloroform; water; dimethyl sulfoxide; toluene;