3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

Base Information

Chemical Name:3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester
CAS No.:327159-88-6
Molecular Formula:C₄₈H₇₀Cl₃N₅O₁₅Si
Molecular Weight:1091.55
Hs Code.:

3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-<i>tert</i>-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

Synonyms:3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

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Chemical Property of 3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

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Technology Process of 3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

There total 7 articles about 3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(trimethylsilyl)ethoxymethoxy chloride

: 327159-88-6
3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran

2: IPCF; Et₃N; DMAP / CH₂Cl₂

3: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate; methanol

4: BOP-Cl; NMM

With 4-methyl-morpholine; dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; isopropyl chloroformate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(00)00585-0

Reference yield:

: (2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

: 327159-88-6
3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: IPCF; Et₃N; DMAP / CH₂Cl₂

2: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate; methanol

3: BOP-Cl; NMM

With 4-methyl-morpholine; dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; isopropyl chloroformate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(00)00585-0

Reference yield:

: 327159-84-2
(2S,3R)-3-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

: 327159-88-6
3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate; methanol

2: BOP-Cl; NMM

With 4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(00)00585-0