1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

Base Information

• Chemical Name: 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose
• CAS No.: 1357160-42-9
• Molecular Formula: C₄₂H₄₅NO₇
• Molecular Weight: 675.822

Synonyms:1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

Chemical Property of 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

There total 2 articles about 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-O-tosyl-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose (1357160-39-4) + 4-methoxy-aniline (104-94-9) → 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose (1357160-42-9)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 100 ℃; for 1h; under 1551.49 Torr; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.12.049

Reference yield:

3,4,5,7-tetra-O-benzyl-α-D-glycero-D-xylo-hept-2-ulopyranose (85398-14-7) → 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose (1357160-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 1 h / 100 °C / 1551.49 Torr / Microwave irradiation

With dmap; potassium carbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2011.12.049

Reference yield: 73.0%

1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose (1357160-42-9) + tert-butyl (N-triethylammonium sulfonyl)carbamate → (5S,7R,8R,9S,10R)-8,9,10-tri(benzyloxy)-7-(benzyloxymethyl)-1-(tert-butyloxy)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-2,2-dioxide (1357160-47-4)

Guidance literature:

In tetrahydrofuran; at 75 ℃;

DOI:10.1016/j.tetlet.2011.12.049

upstream raw materials:

1-O-tosyl-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

4-methoxy-aniline

3,4,5,7-tetra-O-benzyl-α-D-glycero-D-xylo-hept-2-ulopyranose

Downstream raw materials:

(5S,7R,8R,9S,10R)-8,9,10-tribenzyloxy-7-(benzyloxymethyl)-N-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-2,2-dioxide

(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-N-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-2,2-dioxide

(5S,7R,8R,9S,10R)-8,9,10-tri(benzyloxy)-7-(benzyloxymethyl)-1-(tert-butyloxy)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-2,2-dioxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1357160-42-9 1-deoxy-1-(p-methoxyphenylamino)-3,4,5,7-tetra-O-benzyl-D-gluco-hept-2-ulopyranose

Send

Send

Metric Ton KG G Pound L ML

Send

Send