3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

Base Information

• Chemical Name: 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
• CAS No.: 486460-20-2
• Molecular Formula: C6H3F3N4
• Molecular Weight: 188.112
• Mol file: 486460-20-2.mol

Synonyms:1,2,4-Triazolo[4,3-a]pyrazine,3-(trifluoromethyl)-;

Chemical Property of 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

Chemical Property:

• Refractive Index: 1.606
• PKA: -2.40±0.30(Predicted)
• PSA: 43.08000
• Density: 1.69 g/cm³
• LogP: 1.14310
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine can be used as reactant/reagent in synthetic preparation of 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for treatment or prevention of diabetes.

Technology Process of 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

There total 7 articles about 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(1-bromo-2,2,2-trifluoroethylidene)-1-(pyrazin-2-yl)hydrazine (1447800-65-8) → 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine (486460-20-2)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 1h;

DOI:10.2174/1570178611310050008

Reference yield: 71.0%

(1,2)-bis-trifluoroacetyl-1-pyrazinylhydrazide → 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine (486460-20-2)

Guidance literature:

With phosphoric acid; at 75 ℃; for 5h; Large scale;

DOI:10.1021/op0500786

Reference yield: 67.3%

2,2,2-trifluoro-N′-(pyrazin-2-yl)acetohydrazide → 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine (486460-20-2)

Guidance literature:

With sulfuric acid; at 0 - 85 ℃; for 12h;

DOI:10.1080/10426507.2019.1577845

upstream raw materials:

2-hydrazinylpyrazine

trifluoroacetic acid

trifluoroacetic anhydride

2-(2,2,2-trifluoroethylidene)-1-(pyrazin-2-yl)hydrazine

Downstream raw materials:

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)propoxy)quinazolin-4-amine

3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Sitagliptin hydrochloride

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Refernces

• 1、 Mannam, Madhava Rao,Devineni, Subba Rao,Pavuluri, Chandra Mouli,Chamarthi, Naga Raju,Kottapalli, Raja Sekhara P.. "Urea and thiourea derivatives of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1, 2, 4]triazolo[4,3-a]pyrazine: Synthesis, characterization, antimicrobial activity and docking studies". . p. 922 - 932. Retrieved 2019.
• 2、 -. "Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase". Paragraph 0715. . Retrieved 2017/01/23.