methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate

Base Information

• Chemical Name: methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate
• CAS No.: 180081-34-9
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.324
• Mol file: 180081-34-9.mol

Synonyms:methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate

Chemical Property of methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate

There total 7 articles about methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate (188586-91-6) → methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate (180081-34-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 2585.81 Torr;

DOI:10.1080/15257770.2014.1001074

Reference yield: 27.0%

3-nitro-benzeneacetic acid (1877-73-2) → methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate (180081-34-9)

Guidance literature:

Reference yield:

d-α-amino-m-nitrophenylacetic acid (30077-08-8) → methyl 2-(3-aminophenyl)-2-((tert-butoxycarbonyl)amino)acetate (180081-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane

2: potassium carbonate / tetrahydrofuran / 18 h / 60 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2585.81 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1080/15257770.2014.1001074

upstream raw materials:

3-nitro-benzeneacetic acid

(S)-2-phenylglycine

D-2-tert-butoxycarbonylamino-2-(3-nitrophenyl)-acetic acid

methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

Downstream raw materials:

(RS)-tert-butoxycarbonylamino-(3-cyclohexylaminophenyl)acetic acid methyl ester