methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

Base Information

• Chemical Name: methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate
• CAS No.: 188586-91-6
• Molecular Formula: C₁₄H₁₈N₂O₆
• Molecular Weight: 310.307
• Mol file: 188586-91-6.mol

Synonyms:methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

Chemical Property of methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate

There total 6 articles about methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

D-2-tert-butoxycarbonylamino-2-(3-nitrophenyl)-acetic acid (54895-27-1) + methyl iodide (74-88-4) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate (188586-91-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 60 ℃; for 18h;

DOI:10.1080/15257770.2014.1001074

Reference yield: 35.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 2-amino-2-(3-nitrophenyl)acetate (687631-80-7,76604-97-2) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate (188586-91-6)

Guidance literature:

With sodium hydrogencarbonate; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

d-α-amino-m-nitrophenylacetic acid (30077-08-8) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl) acetate (188586-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / methanol / Inert atmosphere; Cooling with ice; Reflux

2: triethylamine; sodium hydrogencarbonate / dichloromethane / 20 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; In methanol; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

methyl 2-amino-2-(3-nitrophenyl)acetate

d-α-amino-m-nitrophenylacetic acid

(S)-2-phenylglycine

Downstream raw materials:

2-((tert-butoxycarbonyl)amino)-2-(3-nitrophenyl)ethyl methanesulfonate

tert-butyl (2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)-1-(3-nitrophenyl)ethyl)carbamate

tert-butyl (1-(3-aminophenyl)-2-(1-(2-fluoro-6-(trifluoromethyI)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)carbamate

ethyl 4-((3-(1-((tert-butoxycarbonyl)amino)-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1 H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenyl)amino)butanoate