methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

Base Information

Chemical Name:methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate
CAS No.:158469-96-6
Molecular Formula:C₂₁H₃₁NO₅Si
Molecular Weight:405.566
Hs Code.:

Synonyms:methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

Suppliers and Price of methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

Chemical Property:

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Technology Process of methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

There total 1 articles about methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1885-14-9
phenyl chloroformate

: 141277-45-4
methyl (4S)-2-<(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

: 158469-96-6
methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(01)85517-4

Reference yield:

: 158469-96-6
methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

: 141277-39-6
(4S)-4-<(phenoxycarbonyl)(but-2-ynyl)amino>-5-<(tert-butyldimethylsilyl)oxy>propanal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 5h; Yield given;
DOI:10.1016/S0040-4020(01)85517-4

Reference yield:

: 158469-96-6
methyl (4S)-2-<(phenoxycarbonyl)(but-2-ynyl)amino>-3-<(tert-butyldimethylsilyl)oxy> propionate

: 141277-50-1
(2R)-N-(phenyloxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>-3-hydroxy-4-(ethylidene)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 5 h / -78 °C

2: 50 percent / samarium(II) iodide, tert-butanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 0 °C

With samarium diiodide; diisobutylaluminium hydride; tert-butyl alcohol; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;
DOI:10.1016/S0040-4020(01)85517-4