N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide

Base Information

• Chemical Name: N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide
• CAS No.: 1436595-20-8
• Molecular Formula: C₁₂H₁₄N₂O₄S
• Molecular Weight: 282.32
• Mol file: 1436595-20-8.mol

Synonyms:N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide

Chemical Property of N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide

There total 2 articles about N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N,N-diethyl-2-(4-nitrophenyl)ethynesulfinamide (1436596-40-5) → N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide (1436595-20-8)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; ethyl acetate; acetonitrile; at 0 ℃;

DOI:10.1002/chem.201203015

Reference yield:

(4-Nitrophenyl)acetylene (937-31-5) → N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide (1436595-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.33 h / -78 °C / Inert atmosphere

2.1: sodium periodate; ruthenium trichloride / water; acetonitrile; ethyl acetate / 0 °C

With ruthenium trichloride; sodium periodate; potassium hexamethylsilazane; In tetrahydrofuran; water; ethyl acetate; toluene; acetonitrile;

DOI:10.1002/chem.201203015

Reference yield: 69.0%

N,N-diethyl-2-(4-nitrophenyl)ethynesulfonamide (1436595-20-8) + potassium tert-butylate (865-47-4) → tert-butyl 4-nitrophenylacetylenyl ether (1436595-58-2)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/chem.201203015

upstream raw materials:

(4-Nitrophenyl)acetylene

N,N-diethyl-2-(4-nitrophenyl)ethynesulfinamide

Downstream raw materials:

3-(tert-butoxy)-2,4-bis(4-nitrophenyl)cyclobut-2-enone

tert-butyl 4-nitrophenylacetylenyl ether