tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

Base Information

Chemical Name:tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate
CAS No.:1344703-26-9
Molecular Formula:C₁₈H₁₉F₃N₂O₅
Molecular Weight:400.354
Hs Code.:

Synonyms:tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

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Chemical Property of tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

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Technology Process of tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

There total 3 articles about tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1344703-19-0
tert-butyl 5-(2-cyanophenoxy)-4-hydroxy-2-(2,2,2-trifluoroacetamido)pentanoate

: 1344703-26-9
tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1260136

Reference yield:

: 38465-16-6
1,2-epoxy-3-(2-cyanophenyl)propane

: 1344703-26-9
tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With Dess-Martin periodane; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Dess-Martin oxidation;
DOI:10.1055/s-0030-1260136

Reference yield:

: 63959-88-6
tert-butyl N-(trifluoroacetyl)glycinate

: 1344703-26-9
tert-butyl 5-(2-cyanophenoxy)-4-oxo-2-(2,2,2-trifluoroacetamido)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With Dess-Martin periodane; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Dess-Martin oxidation;
DOI:10.1055/s-0030-1260136