63959-88-6

Basic information

• Product Name: Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester
• Synonyms: TFA-Gly-OtBu;tert-butyl N-(trifluoroacetyl)glycinate;TFA-Gly-Ot-Bu;tert-butyl 2-(2,2,2-trifluoroacetamido)acetate;N-trifluoroacetyl tert-butyl glycinate;TFAGlyOtBu
• CAS NO: 63959-88-6
• Molecular Formula: C8H12F3NO3
• Molecular Weight: 227.183
• Mol File: 63959-88-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(63959-88-6)
• EPA Substance Registry System: Glycine, N-(trifluoroacetyl)-, 1,1-dimethylethyl ester(63959-88-6)

Safety Data

• Hazardous Substances Data: 63959-88-6(Hazardous Substances Data)

Upstream product

• 383-70-0 TFA-Gly 
• 115-11-7 isobutene 
• 354-38-1 2,2,2-trifluoroacetamide 
• 6456-74-2 Glycine tert-butyl ester 
• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 383-63-1 ethyl trifluoroacetate, 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 910579-13-4 tert-butyl [(4-bromophenyl)(hydroxy)amino][(trifluoroacetyl)amino]acetate 

Relevant articles and documents

Single Electron Transfer-Induced Selective α-Oxygenation of Glycine Derivatives

Modification of amino acids is an important strategy in organic and bioorganic chemistry. In contrast to common side-chain functionalization, backbone modification is much less explored. Especially glycine units seem to be attractive and versatile since a wide range of functionality can be potentially introduced. We report here oxidative modification of glycinates that are stable and enable further functionalization. Selective glycinate enolate oxidation by TEMPO or a FeCp2PF6/TEMPO reagent combination provides stable alkoxyamines in good to excellent yields. The methodology is expanded to glycine-containing dipeptides demonstrating selective oxygenation at the glycine unit. The orthogonal reactivity potential of oxygenated glycines for transformation to other amino acid derivatives is explored.

SYNTHESIS OF A-AMANITIN AND ITS DERIVATIVES

The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

A straightforward approach towards combined ?-amino and ?-hydroxy acids based on Passerini reactions

Complex amino acids with an ?-acyloxycarbonyl functionality in the side chain are easily available through epoxide opening by chelated enolates and subsequent oxidation/Passerini reaction. This protocol works with both, aldehyde and ketone intermediates, as long as the ketones are activated by electron-withdrawing groups. In principle Ugi reactions are also possible, allowing the generation of diamino acid derivatives.