1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 149666-71-7
• Molecular Formula: C₃₁H₃₀N₂O₆
• Molecular Weight: 526.589
• Mol file: 149666-71-7.mol

Synonyms:1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 10 articles about 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3'-Ac-5'-DMT-cyclothymidine (1025398-91-7) → 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (149666-71-7)

Guidance literature:

With sodium tetrahydroborate; dimethyl ditelluride; ethanol; In tetrahydrofuran;

DOI:10.1021/jo7025806

Reference yield: 46.0%

1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine (143527-01-9) → 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (149666-71-7)

Guidance literature:

With benzyl methyl malonate; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 120h;

DOI:10.3390/molecules26020320

Reference yield:

2-trimethylsilylethanethiol (18143-30-1) + 5'-O-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxythymidine (111647-36-0) → 1-{5-[bis(4-methoxyphenyl)phenyl-methoxymethyl]-2,5-dihydrofuran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (149666-71-7) + 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-trimethylsilanyl-ethylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (1053700-77-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

DOI:10.1021/jo9908492

upstream raw materials:

2-trimethylsilylethanethiol

5'-O-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxythymidine

5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

stavudin