4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole

Base Information

• Chemical Name: 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole
• CAS No.: 1432475-85-8
• Molecular Formula: C₂₄H₁₄N₂O₂
• Molecular Weight: 362.387
• Mol file: 1432475-85-8.mol

Synonyms:4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole

Chemical Property of 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole

There total 6 articles about 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol (1418220-62-8) + benzaldehyde (100-52-7) → 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole (1432475-85-8)

Guidance literature:

In dimethyl sulfoxide; at 158 - 160 ℃; for 10h;

DOI:10.1007/s12039-012-0324-3

Reference yield: 62.0%

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol (1418220-62-8) + benzoic acid (65-85-0,8013-63-6) → 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole (1432475-85-8)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; at 130 - 133 ℃; for 18h;

DOI:10.1007/s12039-012-0324-3

Reference yield:

3-(1,3-benzoxazol-2-yl)naphthalen-2-ol (14967-45-4) → 4-(1,3-benzoxazol-2-yl)-2-phenylnaphtho[1,2-d][1,3]oxazole (1432475-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 55 °C

1.2: 4 h / 0 - 20 °C / pH 8 - 9

2.1: sodium hydroxide; sodium dithionite / water / 2.5 h / 50 - 90 °C / pH 8 - 9

3.1: dimethyl sulfoxide / 10 h / 158 - 160 °C

With hydrogenchloride; sodium dithionite; sodium carbonate; sodium hydroxide; sodium nitrite; In water; dimethyl sulfoxide;

DOI:10.1007/s12039-012-0324-3

upstream raw materials:

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol

benzoic acid

benzaldehyde

2-amino-phenol