N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide
• CAS No.: 1224301-21-6
• Molecular Formula: C₂₂H₂₉NO₄S
• Molecular Weight: 403.543

Synonyms:N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide

Chemical Property of N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide

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Technology Process of N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide

There total 1 articles about N₁-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methyl-1-benzenesulfonamide (1013212-26-4) + propargyl bromide (106-96-7) → N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide (1224301-21-6)

Guidance literature:

N-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methyl-1-benzenesulfonamide; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.02.001

Reference yield: 64.0%

N1-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methylbenzenesulfonamide (1224301-21-6) → (2R)-2-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-1-[(4-methylphenyl)sulfonyl]-5-vinyl-1,2,3,6-tetrahydropyridine (1224301-22-7)

Guidance literature:

With Grubbs catalyst first generation; In benzene; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2010.02.001

upstream raw materials:

N-{(1R)-1-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-3-butenyl}-4-methyl-1-benzenesulfonamide

propargyl bromide

Downstream raw materials:

(2R)-2-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]-1-[(4-methylphenyl)sulfonyl]-5-vinyl-1,2,3,6-tetrahydropyridine

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