allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

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Chemical Name:allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide
CAS No.:1318791-91-1
Molecular Formula:BrH*C₂₄H₂₄N₄O₅
Molecular Weight:529.39
Hs Code.:

Synonyms:allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

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Chemical Property of allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

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Technology Process of allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

There total 3 articles about allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1318791-87-5
6-[4-(3-nitro-benzyloxy)-phenyl]-pyridazin-3-yl amine

: 178215-45-7
4-bromobutyric acid allyl ester

: 1318791-91-1
allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.067

Reference yield:

: 1227266-47-8
4-(6-amino-pyridazin-3-yl)-phenol

: 1318791-91-1
allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With sodium hydride; In N,N-dimethyl-formamide; 1.1: Williamson ether synthesis / 1.2: Williamson ether synthesis;
DOI:10.1016/j.bmcl.2011.05.067

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1318791-91-1
allyl-4-{6-imino-3-[4-(3-nitro-benzyloxy)-phenyl]-6H-pyridazin-1-yl}-butyric acid hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / acetonitrile / 0.17 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; 2.1: Williamson ether synthesis / 2.2: Williamson ether synthesis;
DOI:10.1016/j.bmcl.2011.05.067