5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol

Base Information

• Chemical Name: 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol
• CAS No.: 225114-80-7
• Molecular Formula: C₂₄H₃₄O₂Si₂
• Molecular Weight: 410.704
• Mol file: 225114-80-7.mol

Synonyms:5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol

There total 4 articles about 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(tert-butyldiphenylsilyloxy)-1-propanal (112897-03-7) + trimethylsilylacetylene (1066-54-2) → 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol (225114-80-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

DOI:10.1039/d1ob01944a

Reference yield:

3-(tert-butyldiphenylsilyloxy)propan-1-ol (127047-71-6) → 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol (225114-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DMSO; (COCl)2 / tetrahydrofuran

2: tetrahydrofuran

With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; 1: Oxidation / 2: Condensation;

DOI:10.1039/a807074a

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyl-pent-1-yn-3-ol (225114-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂

2: DMSO; (COCl)2 / tetrahydrofuran

3: tetrahydrofuran

With dmap; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Oxidation / 3: Condensation;

DOI:10.1039/a807074a

upstream raw materials:

lithium trimethylsilylacetylenide

3-(tert-butyldiphenylsilyloxy)-1-propanal

3-(tert-butyldiphenylsilyloxy)propan-1-ol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(R)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-phenylpent-4-ynoic acid

C₂₆H₃₈O₃Si₂

5-(tert-butyl-diphenyl-silanyloxy)-pent-1-yn-3-ol

5-tert-butyldiphenylsilyloxypent-1-yn-3-one