(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

Base Information

Chemical Name:(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt
CAS No.:477533-15-6
Molecular Formula:C₄H₁₁N*C₃₁H₃₈N₂O₅
Molecular Weight:591.791
Hs Code.:

(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

Synonyms:(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

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Chemical Property of (S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

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Technology Process of (S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

There total 8 articles about (S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1355450-60-0
methyl (S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 75-64-9
tert-butylamine

: 477533-15-6
(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

Guidance literature:: methyl (S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

tert-butylamine; In methanol; di-isopropyl ether; for 0.5h; Cooling with ice;
DOI:10.1248/cpb.59.1233

Reference yield:

: 1355450-33-7
(E)-3-(1-methylcyclohexyl)acrylic acid

: 477533-15-6
(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / 20 °C

1.2: 1 h / 0 °C

2.1: toluene / Reflux

3.1: diisobutylaluminium hydride / toluene / 1 h / -40 °C

4.1: triethylamine / dichloromethane / 0.33 h / 0 °C

5.1: tetraethylammonium fluoride; potassium carbonate / toluene / 12 h / 90 °C

6.1: hydrogenchloride; formic acid / isopropyl alcohol / 0.5 h / 20 °C / Cooling with ice

7.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

8.2: 0.5 h / Cooling with ice

With hydrogenchloride; formic acid; thionyl chloride; water; diisobutylaluminium hydride; tetraethylammonium fluoride; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1248/cpb.59.1233

Reference yield:

: 1355450-35-9
(E)-3-(1-methylcyclohexyl)acrylamide

: 477533-15-6
(S)-2-[(2E,4E)-hexa-2,4-dienoyl]-7-(2-{5-methyl-2-[(E)-2-(1-methylcyclohexyl)vinyl]oxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / Reflux

2.1: diisobutylaluminium hydride / toluene / 1 h / -40 °C

3.1: triethylamine / dichloromethane / 0.33 h / 0 °C

4.1: tetraethylammonium fluoride; potassium carbonate / toluene / 12 h / 90 °C

5.1: hydrogenchloride; formic acid / isopropyl alcohol / 0.5 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

7.2: 0.5 h / Cooling with ice

With hydrogenchloride; formic acid; water; diisobutylaluminium hydride; tetraethylammonium fluoride; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1248/cpb.59.1233