N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

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Chemical Name:N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide
CAS No.:1415798-41-2
Molecular Formula:C₂₅H₁₈F₂N₆O₃
Molecular Weight:488.453
Hs Code.:

Synonyms:N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

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Chemical Property of N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

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Technology Process of N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

There total 5 articles about N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 864244-74-6
4-(4-amino-2-fluorophenoxy)pyridin-2-amine

: 1415797-96-4
7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formic acid

: 1415798-41-2
N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

Guidance literature:: 7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

4-(4-amino-2-fluorophenoxy)pyridin-2-amine; In N,N-dimethyl-formamide; at 40 ℃; Inert atmosphere;

Reference yield:

: 5334-41-8
5-amino-4-cyano-1-methylpyrazole

: 1415798-41-2
N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; acetic acid / 6 h / 1551.49 Torr

2.1: piperidine / ethanol / 20 h / Reflux; Inert atmosphere

3.1: pyridine; copper diacetate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 20 h / 20 °C

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 40 °C / Inert atmosphere

With piperidine; pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium hydroxide monohydrate; hydrogen; copper diacetate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 62564-90-3
5-amino-1-methyl-1H-pyrazole-4-carbaldehyde

: 1415798-41-2
N-(4-(2-aminopyridine-4-oxy)-3-fluorophenyl)-7-(4-fluorophenyl)-1-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / ethanol / 20 h / Reflux; Inert atmosphere

2.1: pyridine; copper diacetate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 20 h / 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 40 °C / Inert atmosphere

With piperidine; pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium hydroxide monohydrate; copper diacetate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;