62564-90-3Relevant academic research and scientific papers
A novel approach towards the synthesis of the 3,4,5-trihydro-1,3-diazepin-5-ol ring structure
Acevedo,Krawczyk,Townsend
, p. 4789 - 4792 (1983)
A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin 7 to a primary amine has produced an in situ annulation to generate the 3,4,5-trihydro-1,3-diazepin-5-ol ring. This ring substructure has demonstrated important biological significance.
HETEROCYCLIC PYRIDONE COMPOUND, AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF
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Paragraph 0281; 0282, (2014/08/06)
The present invention relates to a heterocyclic pyridone compound represented by General Formula (I), where the heterocyclic pyridone compound is used as a tyrosine kinase inhibitor, and particularly a c-Met inhibitor. The present invention also relates to intermediates for preparing heterocyclic pyridone compound and a preparation method. The present invention further relates to a pharmaceutical composition containing the heterocyclic pyridone compound as an active ingredient, and a use of the pharmaceutical composition in treatment of diseases associated with tyrosine kinase c-Met, especially cancer associated with c-Met, as a medicament.
Syntheses of o-Aminohetarenecarbaldehydes via Azides
Becher, Jan,Pluta, Krystian,Krake, Niels,Broendum, Klaus,Christensen, Nils Just,Vinader, Maria Victoria
, p. 530 - 533 (2007/10/02)
o-Chlorohetarenecarbaldehydes react with sodium azide at low temperature yielding moderately stable o-azidohetarenecarbaldehydes.With hydrogen sulfide these compounds are reduced to the corresponding stable o-amino aldehydes.Both reaction steps give high
