dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Base Information

Chemical Name:dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
CAS No.:1382649-76-4
Molecular Formula:C₅₂H₆₀N₈O₇
Molecular Weight:909.098
Hs Code.:

dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Synonyms:dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

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Chemical Property of dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

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Technology Process of dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

There total 9 articles about dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1382650-18-1
(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1382649-76-4
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1382649-76-4
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 0.17 h / Inert atmosphere

2.2: 18 h / 70 °C / Inert atmosphere; Microwave irradiation; sealed tube

3.1: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C

4.1: dimethylsulfide borane complex; (+)-α-pinene / tetrahydrofuran / 5.17 h / 0 - 20 °C

4.2: 20 h / 0 - 20 °C / Reflux

4.3: 3 h / 20 °C

5.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

6.1: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

9.1: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

10.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

11.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; copper(l) iodide; dimethylsulfide borane complex; (+)-α-pinene; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 471239-60-8
di-tert-butyl (4-bromobenzene-1,2-diyl)biscarbamate

: 1382649-76-4
dimethyl (2S,2'S)-1,1'-((2S,2'S)-2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 0.17 h / Inert atmosphere

1.2: 18 h / 70 °C / Inert atmosphere; Microwave irradiation; sealed tube

2.1: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C

3.1: dimethylsulfide borane complex; (+)-α-pinene / tetrahydrofuran / 5.17 h / 0 - 20 °C

3.2: 20 h / 0 - 20 °C / Reflux

3.3: 3 h / 20 °C

4.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

5.1: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

8.1: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

9.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; copper(l) iodide; dimethylsulfide borane complex; (+)-α-pinene; boron trifluoride diethyl etherate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;