(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

Base Information

Chemical Name:(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)
CAS No.:1382650-18-1
Molecular Formula:C₃₈H₃₈N₆O
Molecular Weight:594.759
Hs Code.:

Synonyms:(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

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Chemical Property of (S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

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Technology Process of (S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

There total 8 articles about (S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382650-15-8
(2S,2'S)-tert-butyl 2,2'-(5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(1H-benzo[d]imidazole-5,2-diyl))dipyrrolidine-1-carboxylate

: 1382650-18-1
(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1382650-18-1
(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 0.17 h / Inert atmosphere

2.2: 18 h / 70 °C / Inert atmosphere; Microwave irradiation; sealed tube

3.1: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C

4.1: dimethylsulfide borane complex; (+)-α-pinene / tetrahydrofuran / 5.17 h / 0 - 20 °C

4.2: 20 h / 0 - 20 °C / Reflux

4.3: 3 h / 20 °C

5.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

6.1: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

7.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

9.1: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

10.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

With hydrogenchloride; potassium phosphate; copper(l) iodide; dimethylsulfide borane complex; (+)-α-pinene; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 471239-60-8
di-tert-butyl (4-bromobenzene-1,2-diyl)biscarbamate

: 1382650-18-1
(S)-5,5'-(3-(4-(benzyloxy)phenyl)cyclopropane-1,2-diyl)bis(2-((S)-pyrrolidine-2-yl)-1H-benzo[d]imidazole)

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Microwave irradiation; sealed tube

2: boron trifluoride diethyl etherate / dichloromethane; toluene / 1 h / -25 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide / 2 h / 20 °C

5: acetic acid / toluene; tetrahydrofuran / 1 h / 70 °C

6: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

With hydrogenchloride; potassium phosphate; boron trifluoride diethyl etherate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;