(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

Base Information

Chemical Name:(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol
CAS No.:312328-69-1
Molecular Formula:C₂₃H₂₇ClN₂O₄
Molecular Weight:430.931
Hs Code.:

Synonyms:(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

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Chemical Property of (R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

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Technology Process of (R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

There total 1 articles about (R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 66422-84-2
4-benzyloxy-3-chlorobenzaldehyde

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 312328-69-1
(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

Guidance literature:: With n-butyllithium; titanium tris(diethylamido)chloride; at -78 ℃;
DOI:10.1002/1522-2675(20000906)83:9<2572::AID-HLCA2572>3.0.CO;2-X

Reference yield:

: 312328-69-1
(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

: (2S,3R)-3-Acetoxy-2-amino-3-(4-benzyloxy-3-chloro-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: TFA; H₂O / acetonitrile

With pyridine; water; trifluoroacetic acid; In acetonitrile; 1: Acetylation / 2: Ring cleavage;
DOI:10.1002/1522-2675(20000906)83:9<2572::AID-HLCA2572>3.0.CO;2-X

Reference yield:

: 312328-69-1
(R)-(4-Benzyloxy-3-chloro-phenyl)-((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-methanol

: 1027829-80-6
(2S,3R)-2-Allyloxycarbonylamino-3-(4-benzyloxy-3-chloro-phenyl)-3-hydroxy-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: TFA; H₂O / acetonitrile

3: aq. NaHCO₃ / dioxane

4: 91 percent / K₂CO₃ / methanol; H₂O

With pyridine; water; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; water; acetonitrile; 1: Acetylation / 2: Ring cleavage / 3: Condensation / 4: Deacetylation;
DOI:10.1002/1522-2675(20000906)83:9<2572::AID-HLCA2572>3.0.CO;2-X