methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

Base Information

Chemical Name:methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride
CAS No.:1620955-26-1
Molecular Formula:C₂₄H₂₁N₃O₃*ClH
Molecular Weight:435.91
Hs Code.:

Synonyms:methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

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Chemical Property of methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

Chemical Property:

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Technology Process of methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

There total 9 articles about methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-25-0
C₂₉H₂₉N₃O₅

: 1620955-26-1
methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1620955-26-1
methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

1.2: 12 h / 65 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 14 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 191338-94-0
ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

: 1620955-26-1
methyl 2-(4'-(2-aminoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: methanol; diethyl ether / 1 h / 0 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; toluene / 14 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; cesium fluoride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; toluene;