(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

Base Information

Chemical Name:(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate
CAS No.:1312135-77-5
Molecular Formula:C₁₆H₂₀O₅
Molecular Weight:292.332
Hs Code.:

Synonyms:(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

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Chemical Property of (R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

Chemical Property:

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Technology Process of (R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

There total 10 articles about (R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1312136-27-8
C₁₆H₂₂O₅

: 1312135-77-5
(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.3390/molecules16075422

Reference yield:

: C₃₇H₄₂O₅SSi

: 1312135-77-5
(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide / tetrahydrofuran / -78 °C / Inert atmosphere

2: copper(l) cyanide / diethyl ether / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride; water; acetic acid / tetrahydrofuran / 20 °C / Inert atmosphere

4: pyridinium chlorochromate / dichloromethane / 0.5 h / 0 - 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; water; copper(l) cyanide; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.3390/molecules16075422

Reference yield:

: C₂₁H₂₈O₃Si

: 1312135-77-5
(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrachloromethane; sodium hydrogencarbonate; triphenylphosphine / water / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -40 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: trifluorormethanesulfonic acid / dichloromethane / 0 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 - 0 °C / Inert atmosphere

5.1: sodium methylate / methanol / 3 h / 20 °C / Inert atmosphere

6.1: copper(l) iodide / tetrahydrofuran / -78 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride; water; acetic acid / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: pyridinium chlorochromate / dichloromethane / 0.5 h / 0 - 20 °C

With tetrachloromethane; copper(l) iodide; n-butyllithium; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; water; sodium methylate; sodium hydrogencarbonate; acetic acid; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.3390/molecules16075422