(R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate

Base Information

• Chemical Name: (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate
• CAS No.: 1312135-93-5
• Molecular Formula: C₃₂H₄₀O₅Si
• Molecular Weight: 532.752

Synonyms:(R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate

Chemical Property of (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate

Chemical Property:

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Technology Process of (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate

There total 11 articles about (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C37H42O5SSi + methylmagnesium bromide (75-16-1) → (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate (1312135-93-5)

Guidance literature:

methylmagnesium bromide; With copper(l) iodide; In tetrahydrofuran; at -78 - 30 ℃; for 1.5h; Inert atmosphere;

C₃₇H₄₂O₅SSi; In tetrahydrofuran; at -78 - 30 ℃; for 1h; Inert atmosphere;

DOI:10.3390/molecules16075422

Reference yield: 33.0%

C37H42O5SSi + methylmagnesium bromide (75-16-1) → (R)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)hex-2-ynoate (1312135-91-3) + (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate (1312135-93-5)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.3390/molecules16075422

Reference yield: 32.0%

(R)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)hex-2-ynoate (1312135-91-3) + methyllithium (917-54-4) → (R,E)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)-3-methylhex-2-enoate (1312135-93-5)

Guidance literature:

With copper(l) cyanide; In diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.3390/molecules16075422

upstream raw materials:

(R)-tert-butyl(3-(4-methoxybenzyloxy)pent-4-ynyloxy)diphenylsilane

(R)-methyl 6-(tert-butyldiphenylsilyloxy)-4-(4-methoxybenzyloxy)hex-2-ynoate

methyllithium

methylmagnesium bromide

Downstream raw materials:

C₁₆H₂₂O₅

(R,E)-methyl 4-(4-methoxybenzyloxy)-3-methyl-6-oxohex-2-enoate

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