1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane

Base Information

• Chemical Name: 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane
• CAS No.: 953789-37-2
• Molecular Formula: C11H15 Cl2 N . Cl H
• Molecular Weight: 268.614
• Hs Code.: 2923900090
• Mol file: 953789-37-2.mol

Synonyms:1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane;1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane Hydrochloride;2-Chloro-N-(4-chlorophenethyl)propan-1-aMine hydrochloride;BenzeneethanaMine, 4-chloro-N-(2-chloropropyl)-, hydrochloride (1:1);2-chloro-N-(4-chlorophenethyl)propan-1-aMin hydrochloride;Lorcaserin interMediate;Lorcaserin iMpurity B;2-chloro-N-(4-chlorophenethyl)propan-1-aMiniuM chloride

Chemical Property of 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane

Chemical Property:

• PSA: 12.03000
• LogP: 4.29230
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%+ ^*data from raw suppliers

4-Chloro-N-(2-chloropropyl)benzeneethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-N-(2-chloropropyl)benzeneethanamine Hydrochloride is used as a reagent in the synthesis of Lorcaserin (L469890, HCl); a novel selective 5-HT2C-receptor agonist for the treatment of obesity.

Technology Process of 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane

There total 11 articles about 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloro-N-(2-chloro-1-oxopropyl)benzeneacetamide → 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride (953789-37-2)

Guidance literature:

With aluminum (III) chloride; sodium tetrahydroborate; chloro-trimethyl-silane; In tetrahydrofuran; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1071/CH15667

Reference yield: 88.3%

1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane (847063-13-2) → 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride (953789-37-2)

Guidance literature:

With thionyl chloride; In N,N-dimethyl acetamide; toluene; at 50 - 65 ℃; for 3h; Inert atmosphere;

Reference yield: 85.82%

1-((4-chlorophenethyl)amino)propan-2-ol hydrochloride (1030624-41-9) → 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride (953789-37-2)

Guidance literature:

With thionyl chloride; N,N-dimethyl acetamide; In toluene; at 50 - 65 ℃; for 2.5h; Product distribution / selectivity;

upstream raw materials:

1-((4-chlorophenethyl)amino)propan-2-ol hydrochloride

1-[[2-(4-chlorophenyl)ethyl]amino]-2-hydroxypropane

4-chlorophenylethylamine

2-(4-chlorophenyl)-N-(2-hydroxypropyl)acetamide

Downstream raw materials:

(+/-)-Lorcaserin

Lorcaserin hydrochloride

bis((R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) L-(+)-tartarate

2C₁₁H₁₄ClN*C₄H₆O₆

Refernces

• 1、 -. "Method for preparing lorcaserin". Paragraph 0025-0028. . Retrieved 2020/08/22.
• 2、 -. "Preparation method of lorcaserin intermediate". Paragraph 0025. . Retrieved 2017/08/29.