(benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol

Base Information

• Chemical Name: (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol
• CAS No.: 249762-36-5
• Molecular Formula: C₂₄H₁₉NO₄S₂
• Molecular Weight: 449.551

Synonyms:(benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol

Chemical Property of (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol

Chemical Property:

Purity/Quality:

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Technology Process of (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol

There total 3 articles about (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

benzothiophene-2-carboxaldehyde (3541-37-5) + 1-benzenesulfonyl-5-methoxy-1H-indole (56995-12-1) → (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol (249762-36-5)

Guidance literature:

1-benzenesulfonyl-5-methoxy-1H-indole; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

benzothiophene-2-carboxaldehyde; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jm010988n

Reference yield:

benzenesulfonyl chloride (98-09-9) → (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol (249762-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 82 percent / dimethylformamide / 1 h / 20 °C

2.1: n-BuLi; diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 71 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm010988n

Reference yield:

→ (benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanol (249762-36-5)

Guidance literature:

upstream raw materials:

benzothiophene-2-carboxaldehyde

1-benzenesulfonyl-5-methoxy-1H-indole

benzenesulfonyl chloride

Downstream raw materials:

(benzo[b]thiophen-2-yl)(5-methoxy-1-phenylsulfonyl-1H-2-indolyl)methanone

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