2-Chloromethyloxazole

Base Information

• Chemical Name: 2-Chloromethyloxazole
• CAS No.: 185246-17-7
• Molecular Formula: C4H4ClNO
• Molecular Weight: 117.535
• Hs Code.: 2934999090
• Mol file: 185246-17-7.mol

Synonyms:2-(Chloromethyl)-1,3-oxazole;2-(Chloromethyl)oxazole;

Chemical Property of 2-Chloromethyloxazole

Chemical Property:

• Vapor Pressure: 6.681mmHg at 25°C
• Refractive Index: 1.479
• Boiling Point: 143.505 °C at 760 mmHg
• PKA: 0.37±0.10(Predicted)
• Flash Point: 40.591 °C
• PSA: 26.03000
• Density: 1.262 g/cm³
• LogP: 1.41340
• Storage Temp.: Store at -20°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloromethyl-oxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloromethyloxazole

There total 2 articles about 2-Chloromethyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,2,3-triazole (288-36-8) + chloroacetyl chloride (79-04-9) → 2-(chloromethyl)oxazole (185246-17-7)

Guidance literature:

1,2,3-triazole; chloroacetyl chloride; With N-ethyl-N,N-diisopropylamine; In chloroform; at 10 - 20 ℃; for 16h;

In sulfolane; chloroform; at 80 - 120 ℃; for 15h; Time;

Reference yield: 37.0%

(1,3-oxazol-2-yl)methanol (130551-92-7) → 2-(chloromethyl)oxazole (185246-17-7)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 60.0%

2-(chloromethyl)oxazole (185246-17-7) + 1-(1-(2,4-difluorophenyl)-1H-indazol-4-yl)imidazolidin-2-one → 1-[1-(2,4-difluorophenyl)-1H-indazol-4-yl]-3-(1,3-oxazol-2-ylmethyl)imidazolidin-2-one

Guidance literature:

1-(1-(2,4-difluorophenyl)-1H-indazol-4-yl)imidazolidin-2-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

2-(chloromethyl)oxazole; In tetrahydrofuran; mineral oil; at 40 ℃; for 3h;

upstream raw materials:

(1,3-oxazol-2-yl)methanol

1,2,3-triazole

chloroacetyl chloride

Downstream raw materials:

tert-butyl 5-(2-(3-(oxazol-2-ylmethoxy)phenyl)-quinazolin-4-ylamino)-1H-indazole-1-carboxylate

1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile

1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoro-methyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile hydrochloride

1-methyl-6-(4-(2-(1-(oxazol-2-ylmethyl)piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile hydrochloride

Refernces

• 1、 -. "ANTI-BACTERIAL COMPOUNDS". Page/Page column 101. . Retrieved 2017/06/28.
• 2、 -. "4- (IH-INDAZOL-S-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 93. . Retrieved 2008/06/13.