133810-35-2Relevant articles and documents
Syntheses and characterization of 1,1'-bis(3-pyridylethynyl)ferrocene and 1,1'-bis(4-pyridylethynyl)ferrocene
Lindner, Ekkehard,Zong, Ruifa,Eichele, Klaus
, p. 219 - 222 (2001)
Two novel disubstituted ferrocene, 1,1'-bis(3-pyridylethynyl)ferrocene 1 and 1,1'-bis(4-pyridylethynyl)ferrocene 2, were synthesized and fully characterized by elemental analysis, 1H NMR 13C NMR IR, and X-ray crystallography. Compound 1crystallizes in monoclinic, space group Cc, a=17.26?, b=9.77?, c=10.85?, β=105.45; R1 =0.0399, wR2=0.1077, GooF=1.023. The two arms of the ferrocene are parallel, which will play an important role both in the coordination chemistry and electronic communiculion of the ferrocene.
A pillared metal-organic framework incorporated with 1,2,3-triazole moieties exhibiting remarkable enhancement of CO2 uptake
Gao, Wen-Yang,Yan, Wuming,Cai, Rong,Williams, Kia,Salas, Andrea,Wojtas, Lukasz,Shi, Xiaodong,Ma, Shengqian
, p. 8898 - 8900 (2012)
The replacement of the pillar ligand, 4,4′-bipyridine, in the prototypal pillared MOF, MOF-508, with the custom-designed ligand, 4,4′-(2H-1,2,3-triazole-2,4-diyl)dipyridine, affords a porous metal-triazolate framework, MTAF-3, which demonstrates remarkable enhancement of CO2 uptake capacity by a factor of ～3 compared to the parent MOF-508.
General method for the preparation of alkyne-functionalized oligopyridine building blocks
Ziessel, Raymond,Suffert, Jean,Youinou, Marie-Therese
, p. 6535 - 6546 (1996)
A large series of alkyne-substituted oligopyridines based on 2,2′-bipyridine, 1,10-phenanthroline, 2,2′:6′,2″-terpyridine, or 1,8-naphthyridine substrates has been synthesized and fully characterized. The palladium(0)-catalyzed coupling of bromo- or chloro-substituted derivatives with (trimethylsilyl)-acetylene proceeds readily in diisopropylamine under ambient conditions giving good yields of the corresponding alkyne-substituted substrates oligoPy(C≡C)SiMe3. The terminal monoynes oligoPyC≡CH become available upon treatment with K2CO3 in methanol. Stepwise homologation of the acetylene function by Cadiot-Chodkiewicz coupling of oligoPyC≡CH with (bromoethynyl)-triethylsilane (BrC≡CSiEt3) affords, in good yield, the silylated diynes oligoPy(C≡C)2SiEt3, from which the terminal diynes oligoPy(C≡C)2H are formed by treatment with aqueous methanolic alkali. Reaction of oligoPy(C≡C)2H with BrC≡CSiEt3 yields the silylated triynes oligoPy(C≡C)3SiEt3 in modest yield. Further homologation is limited by nucleophilic attack of n-propylamine at the C-2 carbon of the alkyne chain, giving rise to a mixture of cis/cis (48%), cis/trans (33%), and trans/ trans (19%) enaminediyne compounds 21a-c. Glaser oxidative self-coupling of the terminal diynes provides access to ditopic bipyridine or terpyridine ligands oligoPy(C≡C)4oligoPy comprising a tetrayne spacer. Quantitative formation of air-stable copper(I) complexes is described for the 6,6′-substituted ligands. A single crystal X-ray structure of complex 22a shows that the two ligands are interlocked around the copper(I) center in a pseudotetrahedral arrangement, similar to the structure deduced from NMR and FAB+ data. The synthetic methods reported herein represent a valuable approach to the large-scale preparation of alkyne-functionalized oligopyridines.
Molecular platforms as versatile building blocks for multifunctional photoswitchable surfaces
Rusch, Talina R.,Hammerich, Melanie,Herges, Rainer,Magnussen, Olaf M.
, p. 9511 - 9514 (2019)
Controlled attachment of photoswitchable molecules to solid surfaces is a promising route for the realization of complex machine-like molecular functions. A central next step here is the preparation of adlayers with multiple chemical functions that have defined intermolecular spacings and orientations and interact with each other in a controlled way, resulting in novel advanced system properties. We demonstrate that this is possible using molecular platforms with vertical functional units. Employing molecular components with identical triazatriangulenium-based units, we prepared mixed adlayers of platforms carrying a stable photoswitch and bare platforms, platforms with vertical pyridine units, and platforms with metastable switches, respectively. All these mixed layers are highly hexagonally ordered, can be easily varied in composition, and exhibit a stochastic arrangement of the two molecular components.
COMPOUNDS AS CASEIN KINASE INHIBITORS
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Paragraph 00416-00417; 00420-00421, (2021/10/02)
Provided are novel casein kinase inhibitors, or pharmaceutically acceptable salts thereof. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also provided.
Synthesis, Electrochemistry, and Optical Properties of Highly Conjugated Alkynyl-Ferrocenes and -Biferrocenes
Bennett, Troy L. R.,Wilkinson, Luke A.,Lok, Jasmine M. A.,O'Toole, Robert C. P.,Long, Nicholas J.
, p. 1156 - 1162 (2021/05/06)
Sonogashira reactions are utilized herein to react iodo-ferrocenes and -biferrocenes with terminal alkyne ligands, functionalized with both pyridine and thioanisole groups. High-yielding reactions generate both monoalkynyl and dialkynyl derivatives, the r
Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors
Keeley,ábrányi-Balogh,Keseru
supporting information, p. 263 - 267 (2019/03/05)
A fragment library of electrophilic small heterocycles was characterized through cysteine-reactivity and aqueous stability tests that suggested their potential as covalent warheads. The analysis of theoretical and experimental descriptors revealed correlations between the electronic properties of the heterocyclic cores and their reactivity against GSH that are helpful in identifying suitable fragments for cysteines with specific nucleophilicity. The most important advantage of these fragments is that they show only minimal structural differences from non-electrophilic counterparts. Therefore, they could be used effectively in the design of targeted covalent inhibitors with minimal influence on key non-covalent interactions.
