[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

Base Information

Chemical Name:[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate
CAS No.:1612895-69-8
Molecular Formula:C₃₇H₃₅Cl₂F₂N₃O₇
Molecular Weight:742.604
Hs Code.:

[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

Synonyms:[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

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Chemical Property of [(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

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Technology Process of [(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

There total 10 articles about [(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(3R)-quinuclidin-3-yl] carbonochloridate hydrochloride

: C₂₉H₂₄Cl₂F₂N₂O₅

: 1612895-69-8
[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

Guidance literature:: In acetonitrile; at 80 ℃; for 0.05h; Microwave irradiation;

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1612895-69-8
[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C / Resolution of racemate

4.1: potassium tert-butylate / methanol / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 21 h / 20 °C

7.1: acetic acid / dichloromethane / 72 h / 20 °C

7.2: 24 h / 20 °C

8.1: acetonitrile / 0.05 h / 80 °C / Microwave irradiation

With dmap; potassium tert-butylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1611454-85-3
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-formylbenzoate

: 1612895-69-8
[(1 )-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2,6-difluoro-N-[(3R)-quinuclidin-3-yl]oxycarbonylanilino)methyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 72 h / 20 °C

1.2: 24 h / 20 °C

2.1: acetonitrile / 0.05 h / 80 °C / Microwave irradiation

With acetic acid; In dichloromethane; acetonitrile;