2-isopropoxy-3-methoxy-5-nitrostyrene

Base Information

• Chemical Name: 2-isopropoxy-3-methoxy-5-nitrostyrene
• CAS No.: 753031-06-0
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.255
• Mol file: 753031-06-0.mol

Synonyms:2-isopropoxy-3-methoxy-5-nitrostyrene

Chemical Property of 2-isopropoxy-3-methoxy-5-nitrostyrene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-isopropoxy-3-methoxy-5-nitrostyrene

There total 2 articles about 2-isopropoxy-3-methoxy-5-nitrostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + 2-isopropoxy-3-methoxy-5-nitrobenzaldehyde → 2-isopropoxy-3-methoxy-5-nitrostyrene (753031-06-0)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

2-isopropoxy-3-methoxy-5-nitrobenzaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ja048794v

Reference yield:

5-nitro-o-vanilline (17028-61-4) → 2-isopropoxy-3-methoxy-5-nitrostyrene (753031-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃; Cs₂CO₃ / dimethylformamide / 0.17 h / 20 °C

1.2: dimethylformamide / 40 °C

2.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

2.2: tetrahydrofuran / -78 - 20 °C

With n-butyllithium; potassium carbonate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2.2: Wittig olefination;

DOI:10.1021/ja048794v

Reference yield: 46.0%

dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) (246047-72-3) + 2-isopropoxy-3-methoxy-5-nitrostyrene (753031-06-0) → RuCl2CHC6H2OCH3NO2OCH(CH3)2(C3H4(N(CH3)3C6H2)2)

Guidance literature:

With copper(l) chloride; In dichloromethane; ligand was reacted with Ru-complex in CH2Cl2 in the presence of CuCl at 30-40°C for 15-60 min; flash chromy.;

DOI:10.1021/ja048794v

upstream raw materials:

Methyltriphenylphosphonium bromide

5-nitro-o-vanilline