methyl 4-benzhydrylbenzoate

Base Information

• Chemical Name: methyl 4-benzhydrylbenzoate
• CAS No.: 34823-78-4
• Molecular Formula: C₂₁H₁₈O₂
• Molecular Weight: 302.373
• Mol file: 34823-78-4.mol

Synonyms:methyl 4-benzhydrylbenzoate

Chemical Property of methyl 4-benzhydrylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 4-benzhydrylbenzoate

There total 12 articles about methyl 4-benzhydrylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzophenone tosylhydrazone (4545-20-4) + 4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-benzhydrylbenzoate (34823-78-4)

Guidance literature:

With [1,1′-biphenyl]-2-yldiphenylphosphane; ammonium acetate; ammonium formate; palladium diacetate; caesium carbonate; In tert-Amyl alcohol; at 90 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol400690t

Reference yield: 87.0%

(diphenyl)methyl 2,3,4,5,6-pentafluorobenzoate + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4-benzhydrylbenzoate (34823-78-4)

Guidance literature:

With [(η³-1-^tBu-indenyl)Pd(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(Cl)]; potassium carbonate; In ethanol; toluene; at 40 ℃; for 4h; Inert atmosphere; Glovebox;

DOI:10.1021/acs.organomet.1c00085

Reference yield: 86.0%

4-(α-hydroxy-benzhydryl)-benzoic acid methyl ester (197526-11-7) → methyl 4-benzhydrylbenzoate (34823-78-4)

Guidance literature:

4-(α-hydroxy-benzhydryl)-benzoic acid methyl ester; With sodium tetrahydroborate; In acetonitrile; at 0 ℃; for 0.25h; Inert atmosphere;

With chloro-trimethyl-silane; potassium iodide; In acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153519

upstream raw materials:

diazomethane

4-benzhydrylbenzoic acid

methanol

Methyl-tritylazocarboxylat

Downstream raw materials:

4-diphenylphosphinylbenzenecarboxylic acid 4-[N-(3-trimethoxysilylpropyl)amide]

1-(4-benzhydryl-phenyl)-2,2,2-triphenyl-ethanone