(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Base Information

Chemical Name:(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene
CAS No.:481656-27-3
Molecular Formula:C₂₂H₃₂O
Molecular Weight:312.495
Hs Code.:

Synonyms:(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Suppliers and Price of (1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

There total 7 articles about (1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 481656-15-9
(1S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ-trimethyl-5-(methylene)decahydronaphthalene

: 481656-27-3
(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Guidance literature:: With rhodium(III) chloride; In ethanol; for 23h; Heating;
DOI:10.1021/ol0271032

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 481656-27-3
(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium; liquid ammonia / tetrahydrofuran / 1 h / Heating

1.2: 72 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 86 percent / potassium tert-butoxide / benzene / 12 h / Heating

3.1: 97 percent / 4M HCl / tetrahydrofuran / 2 h / 20 °C

4.1: 80 percent / hydrogen; triethylamine / 10percent Pd/C / methanol / 16 h / 20 °C / 760.05 Torr

5.1: 100 percent / potassium tert-butoxide / benzene / 12 h / Heating

6.1: 100 percent / RhCl₃*3H₂O / ethanol / 23 h / Heating

With hydrogenchloride; rhodium(III) chloride; potassium tert-butylate; ammonia; hydrogen; lithium; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; benzene; 2.1: Wittig reaction / 5.1: Wittig reaction;
DOI:10.1021/ol0271032

Reference yield:

: 26742-33-6
(4aS)-1,4aβ-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione-5-ethyeneacetal

: 481656-27-3
(1S,2S,4aS,8aR)-1α-(2-methoxybenzyl)-1β,2β,4aβ,5-tetramethyl-1,2,3,4,4a,7,8,8aα-octahydronaphthalene

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium; liquid ammonia / tetrahydrofuran / 1 h / Heating

1.2: 72 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 86 percent / potassium tert-butoxide / benzene / 12 h / Heating

3.1: 97 percent / 4M HCl / tetrahydrofuran / 2 h / 20 °C

4.1: 80 percent / hydrogen; triethylamine / 10percent Pd/C / methanol / 16 h / 20 °C / 760.05 Torr

5.1: 100 percent / potassium tert-butoxide / benzene / 12 h / Heating

6.1: 100 percent / RhCl₃*3H₂O / ethanol / 23 h / Heating

With hydrogenchloride; rhodium(III) chloride; potassium tert-butylate; ammonia; hydrogen; lithium; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; benzene; 2.1: Wittig reaction / 5.1: Wittig reaction;
DOI:10.1021/ol0271032