tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate
• CAS No.: 1364569-59-4
• Molecular Formula: C₂₃H₂₃N₃O₅S
• Molecular Weight: 453.519
• Mol file: 1364569-59-4.mol

Synonyms:tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate

Chemical Property of tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate

There total 2 articles about tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-5-thiophen-2-yl-phenylamine (849235-53-6) + tert-butyl (4-(chlorocarbonyl)benzyl)carbamate (168920-39-6) → tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate (1364569-59-4)

Guidance literature:

In pyridine; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2012.01.053

Reference yield:

4-(tert-Butoxycarbonylaminomethyl)benzoic acid (33233-67-9) → tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate (1364569-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / pyridine / 3 h / 20 °C / Inert atmosphere

2: pyridine; N,N-dimethyl-formamide / 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.053

Reference yield: 99.0%

tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate (1364569-59-4) → 4-(aminomethyl)-N-(2-nitro-5-(thiophen-2-yl)phenyl)benzamide hydrochloride (1364569-65-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.bmcl.2012.01.053

upstream raw materials:

2-nitro-5-thiophen-2-yl-phenylamine

tert-butyl (4-(chlorocarbonyl)benzyl)carbamate

4-(tert-Butoxycarbonylaminomethyl)benzoic acid

Downstream raw materials:

4-(aminomethyl)-N-(2-nitro-5-(thiophen-2-yl)phenyl)benzamide hydrochloride

C₂₃H₂₂N₄O₅S

4-ethyl-N-(4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-2,3-dioxopiperazine-1-carboxamide

C₂₄H₂₅N₅O₄S