[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

Base Information

Chemical Name:[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol
CAS No.:876288-73-2
Molecular Formula:C₃₂H₃₈Br₂O₆
Molecular Weight:678.458
Hs Code.:

Synonyms:[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

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Chemical Property of [(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

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Technology Process of [(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

There total 7 articles about [(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 909001-62-3
[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

: 876288-73-2
[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1.5h;
DOI:10.1016/j.tetlet.2005.11.085

Reference yield:

: 876288-69-6
(1'R,3'S,4'R,6'R,8'S,10'R)-3'-(tret-butyldimethylsilyloxymethyl)-6'-methyl-10'-phenyl-2',9',11'-trioxabicyclo[6.4.0]dodecan-4'-yl 2,2-dimethylpropionate

: 876288-73-2
[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / HS(CH₂)2SH; NaHCO₃ / Zn(OTf)2 / CH₂Cl₂ / 2 h / 0 - 25 °C

2: 100 percent / NaH; Bu₄NI / tetrahydrofuran / 14 h / 25 °C

3: 88 percent / DIBALH / CH₂Cl₂ / 1.5 h / -78 °C

4: NaH; Bu₄NI / tetrahydrofuran / 21 h / 26 °C

5: Bu₄NF / tetrahydrofuran / 1.5 h / 0 °C

With tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; ethane-1,2-dithiol; zinc trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.11.085

Reference yield:

: 475641-60-2
(2R,4aR,6S,7R,9S,10aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 876288-73-2
[(2S,3R,5S,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridine / 14 h / 26 °C

2: 88 percent / HS(CH₂)2SH; NaHCO₃ / Zn(OTf)2 / CH₂Cl₂ / 2 h / 0 - 25 °C

3: 100 percent / NaH; Bu₄NI / tetrahydrofuran / 14 h / 25 °C

4: 88 percent / DIBALH / CH₂Cl₂ / 1.5 h / -78 °C

5: NaH; Bu₄NI / tetrahydrofuran / 21 h / 26 °C

6: Bu₄NF / tetrahydrofuran / 1.5 h / 0 °C

With pyridine; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; ethane-1,2-dithiol; zinc trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.11.085