[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane
CAS No.:909001-62-3
Molecular Formula:C₄₈H₅₆Br₂O₆Si
Molecular Weight:916.863
Hs Code.:

[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

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Chemical Property of [(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

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Technology Process of [(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

There total 5 articles about [(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876288-69-6
(1'R,3'S,4'R,6'R,8'S,10'R)-3'-(tret-butyldimethylsilyloxymethyl)-6'-methyl-10'-phenyl-2',9',11'-trioxabicyclo[6.4.0]dodecan-4'-yl 2,2-dimethylpropionate

: 909001-62-3
[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / HS(CH₂)2SH; NaHCO₃ / Zn(OTf)2 / CH₂Cl₂ / 2 h / 0 - 25 °C

2: 100 percent / NaH; Bu₄NI / tetrahydrofuran / 14 h / 25 °C

3: 88 percent / DIBALH / CH₂Cl₂ / 1.5 h / -78 °C

4: NaH; Bu₄NI / tetrahydrofuran / 21 h / 26 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; ethane-1,2-dithiol; zinc trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.11.085

Reference yield:

: 475641-60-2
(2R,4aR,6S,7R,9S,10aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 909001-62-3
[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridine / 14 h / 26 °C

2: 88 percent / HS(CH₂)2SH; NaHCO₃ / Zn(OTf)2 / CH₂Cl₂ / 2 h / 0 - 25 °C

3: 100 percent / NaH; Bu₄NI / tetrahydrofuran / 14 h / 25 °C

4: 88 percent / DIBALH / CH₂Cl₂ / 1.5 h / -78 °C

5: NaH; Bu₄NI / tetrahydrofuran / 21 h / 26 °C

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; ethane-1,2-dithiol; zinc trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2005.11.085

Reference yield:

: 876288-72-1
(2S,3R,5S,7S,8R)-7-(4-bromobenzyloxy)-8-(4-bromobenzyloxymethyl)-2-(tret-butyldimethylsilyloxymethyl)-5-methyl-oxocan-3-ol

: 2746-25-0
p-Methoxybenzyl bromide

: 909001-62-3
[(2S,3R,5R,7S,8R)-7-(4-Bromo-benzyloxy)-8-(4-bromo-benzyloxymethyl)-3-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-ylmethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 26 ℃; for 21h;
DOI:10.1016/j.tetlet.2005.11.085