7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine

Base Information

Chemical Name:7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine
CAS No.:119011-56-2
Molecular Formula:C₆H₄ClN₃S₂
Molecular Weight:217.703
Hs Code.:2933399990
European Community (EC) Number:852-809-0
Mol file:119011-56-2.mol

Synonyms:119011-56-2;7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine;7-chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine;7-chloro-2-methylsulfanyl-[1,3]thiazolo[4,5-d]pyrimidine;7-chloro-2-methylsulfanyl-thiazolo[4,5-d]pyrimidine;MFCD09837036;C6H4ClN3S2;SCHEMBL4477705;AMY2137;QWLDSUKDTJSCCY-UHFFFAOYSA-N;CS1392;AKOS000280717;AKOS024462458;AS-46518;CS-0453056;EN300-58971;A892762;Thiazolo[4,5-d]pyrimidine, 7-chloro-2-(methylthio)-;7-chloro-2-(methylthio)[1,3]thiazolo[4,5-d]pyrimidine;Z600584216;7-chloro-2-(methylsulfanyl)[1,3]thiazolo[4,5-d]pyrimidine

Suppliers and Price of 7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine
10mg
$ 45.00

SynQuest Laboratories
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine
1 g
$ 624.00

Matrix Scientific
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine 95%
250mg
$ 212.00

Matrix Scientific
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine 95%
500mg
$ 341.00

Matrix Scientific
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine 95%
1g
$ 545.00

Crysdot
7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine 95+%
1g
$ 990.00

Apolloscientific
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine
1g
$ 527.00

American Custom Chemicals Corporation
7-CHLORO-2-(METHYLSULFANYL)-[1,3]THIAZOLO[4,5-D]PYRIMIDINE 95.00%
2.5G
$ 1635.30

American Custom Chemicals Corporation
7-CHLORO-2-(METHYLSULFANYL)-[1,3]THIAZOLO[4,5-D]PYRIMIDINE 95.00%
1G
$ 737.10

AK Scientific
7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine
250mg
$ 336.00

Total 8 raw suppliers

Chemical Property of 7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:216.9535172
Heavy Atom Count:12
Complexity:171

Purity/Quality:

97% ^*data from raw suppliers

7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CSC1=NC2=C(S1)C(=NC=N2)Cl
Uses 7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine (cas# 119011-56-2) is used in the synthesis of 2,7-diamino-thiazolo[4,5-d]pyrimidine analogs as anti-tumor epidermal growth factor receptor tyrosine kinase inhibitors. It is also used in the preparation of thiazolopyrimidines and thienopyrimidines as antagonists of CCR2b receptors for the treatment of chemokine-mediated diseases.

Technology Process of 7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine

There total 6 articles about 7-Chloro-2-(methylthio)thiazolo[4,5-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 119011-50-6
2-(Methylthio)thiazolo<4,5-d>pyrimidin-7(6H)-on

: 119011-56-2
7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin

Guidance literature:: With trichlorophosphate; for 2h; Reflux;

Reference yield: 30.0%

: 119011-50-6
2-(methylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one

: 119011-56-2
7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin

Guidance literature:: With trichlorophosphate; for 4h; Heating;

Reference yield:

: 39736-28-2
2-methylmercapto-4-amino-5-cyanothiazole

: 119011-56-2
7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / H₂O / 5 h / Heating

2: 55 percent / POCl₃ / 2 h / Heating

With water; trichlorophosphate;