7-Chloro-2-(Methylsulfanyl)-[1,3]thiazolo[4,5-d]pyriMidine

Base Information

• Chemical Name: 7-Chloro-2-(Methylsulfanyl)-[1,3]thiazolo[4,5-d]pyriMidine
• CAS No.: 119011-56-2
• Molecular Formula: C₆H₄ClN₃S₂
• Molecular Weight: 217.703
• Hs Code.: 2933399990
• Mol file: 119011-56-2.mol

Synonyms:7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin

Chemical Property of 7-Chloro-2-(Methylsulfanyl)-[1,3]thiazolo[4,5-d]pyriMidine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 7-Chloro-2-(methylsulfanyl)-[1,3]thiazolo[4,5-d]pyrimidine (cas# 119011-56-2) is used in the synthesis of 2,7-diamino-thiazolo[4,5-d]pyrimidine analogs as anti-tumor epidermal growth factor receptor tyrosine kinase inhibitors. It is also used in the preparation of thiazolopyrimidines and thienopyrimidines as antagonists of CCR2b receptors for the treatment of chemokine-mediated diseases.

Technology Process of 7-Chloro-2-(Methylsulfanyl)-[1,3]thiazolo[4,5-d]pyriMidine

There total 6 articles about 7-Chloro-2-(Methylsulfanyl)-[1,3]thiazolo[4,5-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(Methylthio)thiazolo<4,5-d>pyrimidin-7(6H)-on (119011-50-6) → 7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin (119011-56-2)

Guidance literature:

With trichlorophosphate; for 2h; Reflux;

Reference yield: 30.0%

2-(methylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one (119011-50-6) → 7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin (119011-56-2)

Guidance literature:

With trichlorophosphate; for 4h; Heating;

Reference yield:

2-methylmercapto-4-amino-5-cyanothiazole (39736-28-2) → 7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin (119011-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / H₂O / 5 h / Heating

2: 55 percent / POCl₃ / 2 h / Heating

With water; trichlorophosphate;

upstream raw materials:

2-(Methylthio)thiazolo<4,5-d>pyrimidin-7(6H)-on

2-methylmercapto-4-amino-5-cyanothiazole

4-amino-2-(methylsulfanyl)-1,3-thiazole-5-carboxamide

2-(methylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one

Downstream raw materials:

N-(3-(4-methoxybenzyloxy)phenyl)-2-(methylthio)thiazolo[4,5-d]pyrimidin-7-amine

N-(3-(4-methoxybenzyloxy)phenyl)-2-(4-methylpiperazin-1-yl)thiazolo[4,5-d]pyrimidin-7-amine

3-(2-(4-methylpiperazin-1-yl)thiazolo[4,5-d]pyrimidin-7-ylamino)phenol trifluoroacetic acid

(3-chloro-4-fluoro-phenyl)-(2-methylsulfanyl-thiazolo[4,5-d]pyrimidin-7-yl)-amine

Refernces

• 1、 -. "BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY". Paragraph 0471. . Retrieved 2015/06/25.
• 2、 -. "ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME". Paragraph 0318; 0323; 0324. . Retrieved 2013/03/28.